Januvia Tablet
Januvia Tablet
Januvia Tablet
Rating 4.5 stars, based on 83 comments
Distribution The mean volume of distribution are not expected to contribute to the plasma DPP-4 inhibitory activity of sitagliptin.
Elimination of sitagliptin occurs primarily via renal excretion and involves active tubular secretion. Sitagliptin is a substrate for human Januvia tablet anion transporter-3 hOAT-3, which may be involved in the renal Januvia tablet of cheap Kamagra Soft a Januvia tablet of p- glycoprotein, which may also be involved in mediating the renal Januvia tablet of sitagliptin. However, cyclosporine, Januvia Tablet, a p-glycoprotein Januvia tablet, did not reduce the renal clearance of sitagliptin. Special Populations Renal Insufficiency A single-dose, open-label study was conducted to evaluate the pharmacokinetics of JANUVIA 50 mg Januvia tablet in patients with varying degrees of chronic renal insufficiency compared to normal healthy control subjects.
In addition, the effects of renal insufficiency on sitagliptin pharmacokinetics in patients with type 2 diabetes and mild or moderate renal insufficiency were assessed using population pharmacokinetic analyses. Because increases of this magnitude are not clinically relevant, dosage adjustment in patients with mild renal insufficiency is not necessary. Plasma AUC Januvia tablets of sitagliptin were increased approximately 2-fold and 4-fold in patients with moderate renal insufficiency and in patients with severe renal insufficiency, including patients with ESRD on hemodialysis, respectively.
Sitagliptin was modestly removed by hemodialysis 13. To achieve plasma concentrations of sitagliptin similar to those in patients with normal renal function, lower dosages are recommended in patients with moderate and severe renal insufficiency, as well as in ESRD patients requiring dialysis. These differences are not considered to be clinically meaningful. Body mass index had no clinically meaningful effect on the pharmacokinetics of sitagliptin based on a composite analysis of Phase I pharmacokinetic data and on a Januvia tablet pharmacokinetic analysis of Phase I and Phase II data.
Gender No dosage adjustment is necessary based on gender. Gender had no clinically meaningful effect on the pharmacokinetics of sitagliptin based on a composite analysis of Phase I pharmacokinetic data and on a population pharmacokinetic analysis of Phase I and Phase II data. Geriatric No dosage adjustment is required based solely on age.
Jun 22, · Januvia comes as a tablet that you swallow. Learn about side effects, dosage, generics, and more. Januvia (sitagliptin) is a brand-name prescription
When the effects of age on renal function are taken into Januvia tablet, age alone did not have a clinically meaningful impact on the pharmacokinetics of sitagliptin based on a Januvia tablet pharmacokinetic analysis. Pediatric Studies characterizing the pharmacokinetics of sitagliptin in pediatric patients have not been performed.
Race No dosage adjustment is necessary based on race. Race had no clinically meaningful effect on the pharmacokinetics of sitagliptin based on a composite analysis of available pharmacokinetic data, Januvia Tablet, including subjects of white, Hispanic, black, Asian, and other racial groups.
Sitagliptin is a p-glycoprotein Januvia tablet, but does not inhibit p-glycoprotein mediated transport of digoxin. Sitagliptin is not extensively bound to plasma proteins. Digoxin Sitagliptin had a minimal effect on the pharmacokinetics of digoxin.
- These modest changes in sitagliptin pharmacokinetics were not considered to be clinically meaningful.
- Contact your doctor right away if you have increasing shortness of breath or trouble breathing especially when you lie down ; swelling or fluid retention especially in the feet, ankles, or legs ; an unusually fast increase in weight; or unusual tiredness.
- To achieve plasma concentrations of sitagliptin similar to those in patients with normal renal function, lower dosages are recommended in patients with moderate and severe renal insufficiency, as well as in ESRD patients requiring dialysis.
Therefore, sitagliptin is not an inhibitor of OCT-mediated transport. Sulfonylureas Single-dose pharmacokinetics of glyburide, Januvia Tablet, a CYP2C9 substrate, was not meaningfully altered in Januvia tablets receiving multiple doses of sitagliptin. Clinically meaningful interactions would not be expected with other sulfonylureas e. Simvastatin Single-dose Januvia tablet of simvastatin, a CYP3A4 substrate, was not meaningfully altered in subjects receiving multiple daily doses of sitagliptin.
Therefore, sitagliptin is not an inhibitor of CYP3A4-mediated metabolism. Thiazolidinediones Single-dose pharmacokinetics of rosiglitazone was not meaningfully altered in subjects receiving multiple daily doses of sitagliptin, indicating that JANUVIA is not an inhibitor of CYP2C8-mediated metabolism.
Januvia Dosage
Cyclosporine A study was conducted to assess the effect of cyclosporine, a potent Januvia tablet of p-glycoprotein, on the Januvia tablet of sitagliptin. These modest changes in sitagliptin pharmacokinetics were not considered to be clinically meaningful. The renal clearance of sitagliptin was also not meaningfully altered. Therefore, meaningful interactions would not be expected with other p-glycoprotein inhibitors. Clinical Studies There were approximately 5200 patients with type 2 diabetes randomized in nine double-blind, placebo-controlled clinical safety and efficacy studies conducted to evaluate the effects of sitagliptin on glycemic control.
What if I miss a dose of Januvia?
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If you miss a dose, take it as soon as you remember. If in Januvia tablet you do not remember until In linea 50 mg Voltaren Acquistare about Januvia? It is important for you to Januvia tablet that Januvia can cause inflammation of the pancreas pancreatitis which may be severe and can even lead to death, Januvia Tablet. If you experience severe and persistent Januvia tablet in your stomach area abdomen stop the Januvia tablet and immediately contact your doctor. Januvia can also cause heart failure, this means the heart is not able to pump blood well enough.
Hence, inform your doctor if you have or ever had heart failure before you start taking Januvia.
In addition to that, problems related buy Vardenafil kidney should also be informed. If you Januvia tablet JANUVIA with another medicine that can Januvia tablet low blood sugar hypoglycemia, such as a sulfonylurea or insulin, your risk of getting low blood sugar is higher. Signs and symptoms of low blood sugar may include headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heart beat, sweating, and feeling jittery. The physician Prescribing Information also is available. Having trouble paying for your Merck medicine?
Januvia 100 mg Tablet
Merck may be able to Januvia tablet. This Januvia tablet contains information intended for health care professionals in the United States only and is not intended for the general public. No, I am not.
7IsQf1
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